Comparative Analysis of Context-Dependent Mutagenesis Using Human and Mouse Models
نویسندگان
چکیده
منابع مشابه
Comparative Analysis of Context-Dependent Mutagenesis Using Human and Mouse Models
Substitution rates strongly depend on their nucleotide context. One of the most studied examples is the excess of C > T mutations in the CG context in various groups of organisms, including vertebrates. Studies on the molecular mechanisms underlying this mutation regularity have provided insights into evolution, mutagenesis, and cancer development. Recently several other hypermutable motifs wer...
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ژورنال
عنوان ژورنال: BioMed Research International
سال: 2013
ISSN: 2314-6133,2314-6141
DOI: 10.1155/2013/989410